| TN2322 |
Yangambin
|
|
Calcium Channel
,
PAFR
|
|
Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibiti... |
| T6S1418 |
Praeruptorin C
|
|
Antioxidant
,
Calcium Channel
|
|
1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors ... |
| T8787 |
Drotaverine hydrochloride
|
|
PDE
|
|
Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor，and is an antispasmodic drug, used to enhance cervical dilation during childbirth. Drotaverine hydrochloride is structurally rela... |
| T8206 |
Cycleanine
|
|
Others
|
|
Cycleanine has potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities. |
| T0728 |
Ethosuximide
|
Zarontin |
Calcium Channel
|
|
Ethosuximide (Zarontin) is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other types of seizures. |
| T3904 |
Gomisin J
|
|
Calcium Channel
,
AMPK
|
|
Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK... |
| T5723 |
Menthol
|
DL-Menthol |
Others
,
Calcium Channel
|
|
Menthol (DL-Menthol) is an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. |
| T15027 |
Cyclopiazonic acid
|
|
Calcium Channel
|
|
Cyclopiazonic acid (CPA) is a neurotoxic secondary metabolite (SM) made by A. flavus. Cyclopiazonic acid (CPA) is an endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA)nanomolar inhibitor and a potent inducer of ce... |
| T4727 |
Taurolithocholic acid sodium salt
|
Sodium taurolithocholate |
Others
,
Calcium Channel
|
|
Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but not to M2 or M3 receptors. |
| T4S1422 |
Praeruptorin E
|
|
Others
,
Calcium Channel
|
|
1. Praeruptorin C and E can relax swine coronary artery and decrease contractility in guinea-pig left atria, these effects are similar in many respects to those displayed by drugs that have calcium entry blocking activit... |
| T10024 |
1-Octanol
|
Octanol |
Calcium Channel
,
Endogenous Metabolite
|
|
1-Octanol, a saturated fatty alcohol, functions as an inhibitor of T-type calcium channels (T-channels), showing an inhibitory concentration (IC50) of 4 μM for native T-currents[1]. Additionally, 1-Octanol is recognized ... |
| TQ0302 |
Thapsigargin
|
|
Apoptosis
,
SARS-CoV
,
Calcium Channel
|
|
Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking ... |
| T3013 |
Catharanthine tartrate
|
Catharanthine hemitartrate |
Others
,
Calcium Channel
|
|
Catharanthine tartrate (Catharanthine hemitartrate) is an alkaloid from periwinkle that inhibits voltage-gated L-type calcium channels and has antitumor and hypotensive activities. |
| T5S2059 |
Glaucine
|
|
Calcium Channel
,
Dopamine Receptor
,
Influenza Virus
,
Adrenergic Receptor
,
PDE
|
|
Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of h... |
| TN1008 |
Psoralenoside
|
|
CaMK
,
Calcium Channel
,
Histamine Receptor
|
|
Psoralenoside is a natural product isolated from the fruits of Psoralea corylifolia, shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity. |
| T2782 |
Catharanthine
|
(+)-3, 4-Didehydrocoronaridine,(+)-3,4-Didehydrocoronaridine |
Calcium Channel
,
AChR
|
|
Catharanthine ((+)-3,4-Didehydrocoronaridine) suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM). |
| T4590 |
(+)-Kavain
|
Kavain,L-KAWAIN,(R)-KAWAIN |
Calcium Channel
,
GABA Receptor
,
Sodium Channel
,
Monoamine Transporter
|
|
(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B. |
| T6S1500 |
Ginsenoside Rf
|
Ginsenoside-Rf,Panaxoside Rf |
Calcium Channel
,
Endogenous Metabolite
|
|
Ginsenoside Rf (Panaxoside Rf) is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel. |
| TN7108 |
Urolithin C
|
|
Apoptosis
,
Calcium Channel
,
Reactive Oxygen Species
,
IGF-1R
,
Endogenous Metabolite
|
|
Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway. |
| T4S1419 |
(±)-Praeruptorin A
|
Praeruptorin A,(-)-Praeruptorin A |
p38 MAPK
,
Calcium Channel
,
Akt
|
|
1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion ... |
| T5701 |
OPHIOPOGONIN D
|
|
RAAS
,
Calcium Channel
,
NF-κB
,
PPAR
|
|
Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation. |
| T3S1916 |
Heteroclitin D
|
|
Calcium Channel
|
|
1. Heteroclitin D can inhibit L-type calcium channels. 2. Heteroclitin D might be a valuable antitumor promoter or chemopreventor. |
| T7056 |
Dronedarone
|
SR 33589 |
P450
,
Potassium Channel
,
Calcium Channel
,
Sodium Channel
,
Adrenergic Receptor
,
AChR
,
Autophagy
|
|
Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation. |
| T1221 |
Acetylcholine chloride
|
ACh chloride,Pilofrin |
Calcium Channel
,
Endogenous Metabolite
,
AChR
|
|
Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride (Pilofrin) mimics the parasympathomimetic effect of the endogen... |
| T8288 |
14-Deoxyandrographolide
|
|
Apoptosis
,
Others
|
|
14-Deoxyandrographolide is a bioactive compound of Andrographis paniculata with hepatoprotective efficacy. It desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release. |
| T6856 |
Halofuginone
|
Tempostatin,empostatin,RU-19110 |
Calcium Channel
,
DNA/RNA Synthesis
,
Sodium Channel
,
Parasite
,
TGF-beta/Smad
|
|
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal. |
| T11665 |
Ionomycin calcium
|
SQ23377 calcium |
Apoptosis
,
Calcium Channel
,
Antibacterial
,
Antibiotic
,
PKC
|
|
|
| T2946 |
Tanshinone IIA sulfonate sodium
|
Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium |
CaMK
,
P450
,
Calcium Channel
|
|
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor... |
| T3524 |
Halofuginone hydrobromide
|
Tempostatin,RU-19110 (hydrobromide),Stenorol |
Others
,
Calcium Channel
,
DNA/RNA Synthesis
,
Sodium Channel
,
Parasite
,
TGF-beta/Smad
|
|
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce... |
| T3915 |
Ginsenoside Ro
|
Chikusetsusaponin 5,Polysciasaponin P3,Chikusetsusaponin V |
Calcium Channel
,
Reductase
,
Prostaglandin Receptor
|
|
Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with an IC50 of 155 μM. |
| T2878 |
Ginsenoside Rd
|
Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII |
P450
,
Calcium Channel
,
NF-κB
,
COX
,
Endogenous Metabolite
|
|
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors. |
| T2996 |
Tetrandrine
|
NSC-77037,d-Tetrandrine,Hanfangchin A,Fanchinine,Sinomenine A |
Potassium Channel
,
Calcium Channel
|
|
Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the c... |
| T23107 |
Ononetin
|
2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone |
TRP/TRPV Channel
|
|
Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM). |
| T3377 |
L-Phenylalanine
|
(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine |
Calcium Channel
,
Endogenous Metabolite
,
iGluR
|
|
L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels. |
| T0928 |
L-Ascorbic acid
|
Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,L-Ascorbate |
Apoptosis
,
Calcium Channel
,
Reactive Oxygen Species
,
Endogenous Metabolite
|
|
L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-... |
| T6674 |
L-Ascorbic acid sodium salt
|
(+)-Sodium L-ascorbate,Vitamin C sodium salt,Sodium ascorbate,L-Ascorbic acid sodium,Sodium L-ascorbate |
Apoptosis
,
Others
,
Calcium Channel
,
Reactive Oxygen Species
,
Endogenous Metabolite
|
|
L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement. |
| TN1065 |
Hirsutine
|
|
Apoptosis
|
|
Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and anti-arrhythmic activities, it also has vasodilatation acti... |
| TN1121 |
Evocarpine
|
|
Apoptosis
,
cAMP
,
Anti-infection
,
Calcium Channel
,
Antibacterial
|
|
Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels. |
| T3427 |
Polydatin
|
Piceid,Polydotin Peceid |
Apoptosis
,
Mitophagy
,
NF-κB
,
Autophagy
|
|
Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th... |
| T15541 |
Hyperforin dicyclohexylammonium salt
|
Hyperforin DCHA |
Others
|
|
Hyperforin dicyclohexylammonium salt is a transient receptor canonical 6 channel activator with antidepressant effect. It modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. |
| T13297 |
Verruculogen
|
|
Others
|
|
Verruculogen is a toxin produced mainly by Penicillium and Aspergillus spp. Verruculogen inhibits Ca2+-activated K+ channels, and is an M phase inhibitor of the mammalian cell cycle. |
| T82753 |
Celangulin
|
|
|
|
Celangulin, an insecticidal component derived from Celastrus angulatus, functions by activating calcium channels on the plasma membrane, which leads to an increase in intracellular Ca2+ due to influx from the external en... |
| TN2918 |
3-Acetoxy-8(17),13E-labdadien-15-oic acid
|
|
cAMP
,
Potassium Channel
,
Calcium Channel
|
|
ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the labdane involve the activation of the endothelial NO-cGMP pathway, the ... |
| T74193 |
(R)-IDHP
|
|
|
|
(R)-IDHP, an isomer of IDHP and a metabolite of salvia, exhibits vasorelaxant properties by inhibiting calcium (Ca 2+) release and inward flow through both voltage-dependent and receptor-operated calcium channels in vasc... |
